Got space on hdd, removed Daemon Tools, scanned with zip integrity check (no corrupt zips in my roms folders, but there are corrupt zips in my unemu roms cds, and that was never a problem before).
Only thing left is the cmpro temp path.... Maybe cmpro is setting the temp path to the cd drive (read-only)? Dunno... I stopped updating my mame/cmpro stuff since 0.67, missed lots of updates, then when i got this new cmpro i just unzipped it over my older version (v2.89.1, or cmp2891.zip), was too lazy to set all those rom paths/add paths/system paths over again :)
Any other suggestions?