Do you use a lot profiles (e.g. > 100)?
Did you use any of floating around settings/profile creators for clrmamepro? If so, tough luck, they create profiles in a wrong way so they get loaded slowly.
If not, well, then I still suspect something's interfearing heavily. Usually virusscanners do that, maybe you should exclude cmpro's settings/datfile folder from any virusscanner background task settings...

Maybe the profiler popupmenu option "garbage-collection" helps you to clean up some stuff.


Roman Scherzer