Mainly runs flat out* on my Pentium4 3.2GHz Extreme Edition. Remember to edit the file called "default" in the Languages subfolder to put English at the top if you want your error messages in English rather than Japanese!

*tried the following:
Daytona USA (USA)
Panzer Dragoon Zwei (JAP)
Sega Rally Championship (EUR)
Thunderforce V (EUR)
Virtua Racing (US)

The only really notable things are problems with sound sometimes (no sound effects in Daytona USA) and Virtua Racing cannot be started (attract mode works) - this also happens on the real Saturn game (rather than an ISO) in the emulator so it seems to be a bug.